His arch enemies are the sinister six, venom, Doctor Octopus and the Green Goblin. But, Spider-Man has one of the biggest selection of enemies alongside Batman and The Flash.
Peter Parker's first girlfriend was Gwen Stacey but she was killed when the Green Goblin threw her off of a bridge and when Spider-Man swung to catch her he missed so he spun a web to catch her but it caught her neck and when it tightened it snapped her neck.
His second girlfriend was Mary Jane Watson. She was never killed and is still in the comics today.
There has been four live action films of Spider-Man. There was Spider-Man 1-3 with Tobey Maguire and then there was the new Amazing Spider-Man with Andrew Garfield.
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